Alzheimer's disease (AD) is the most common neurodegenerative disease primarily effects older adults Alzheimer's disease is an irreversible, progressive brain disease that causes progressive memory loss and thinking skills, and eventually even the ability to carry out the simplest tasks. In most people with Alzheimer's, symptoms first appear after age 65.Alzheimer's disease results from a combination of genetic, lifestyle and environmental factors that affect the brain over time.
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Cerebrospinal fluid (CSF) biomarkers ?-amyloid 1-42 (A?1-42), also expressed as A?1-42:A?1-40 ratio, T-tau, and P-tau181P, have proven diagnostic accuracy for mild cognitive impairment and Alzheimer's disease (AD).
Genetic studies of AD have dentified pathogenic mutations in three genes (APP, PSEN1 and PSEN2) and polymorphisms in APOE as risk factors.
People with Alzheimer's may experience Depression, Anxiety, Social withdrawal, Mood swings, Irritability and aggressiveness, Delusions, such as believing something has been stolenIt is important to obtain a complete history not only from the patient but also from someone who knows the patient well. In addition, a family history of AD or other forms of dementia should be noted.