Hereditary Breast and Ovarian Cancer (HBOC) should be considered when there are multiple cases of breast cancer and/or ovarian cancer on the same side of the family. HBOC is an inherited genetic condition. This means that the cancer risk is passed from generation to generation in a family. Two genes are associated with the majority of HBOC: BRCA1 and BRCA2 (BRCA stands for BReast CAncer). Other less common genes have also been associated with an increased risk of developing breast and other cancers, such as mutations in the TP53, PTEN, CDH1, ATM, CHEK2 or PALB2 tumor suppression genes and many others. A mutation (alteration) in either BRCA1 or BRCA2 gives a
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woman an increased lifetime risk of developing breast and ovarian cancers. Men with these gene mutations also have an increased risk of breast cancer and prostate cancer.