Brugada syndrome is a genetic disease that is characterised by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. The gene, named SCN5A, is located on the short arm of the third chromosome (3p21). Loss-of-function mutations in this gene lead to a loss of the
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action potential dome of some epicardial areas of the right ventricle. This results in transmural and epicardial dispersion of repolarization that often results in sudden cardiac death.