Reward PointsEarn 100 points for writing a review for this product

Mapmygenome offers Chromosomal Microarray Analysis for prenatal and postnatal screening. Over 6,50,000 markers are analysed for Copy Number Variants associated with congenital anomalies, developmental disorders, metabolic diseases, and other known conditions. Our technology is capable of detecting CNVs as small as 30MB CNV regions as well as Copy neutral loss of heterozygosity (Cn-LOH) region based on intensity and SNP genotype. Pre-test and post-test genetic counselling by our experts can help parents and physicians in making informed choices.

Deliverables include:

  • Clinical report.
  • Pre-test and post test genetic counseling.
  • Recommendations and guidelines from our genetic counselor, including further tests.
postnatal

Enquire Now




A quick, reliable, accurate, cost-effective genetic test to give you the diagnosis for clinical management & care.

WHAT IS CHROMOSOMAL MICROARRAY?

Across the globe, chromosomal microarray (CMA) is quickly replacing traditional karyotyping as a first-tier genetic test to screen for suspected chromosomal anomalies, developmental disorders, epilepsy, hypotonia, multiple congenital anomalies, certain metabolic diseases, and other known conditions caused due to cytogenetic abnormalities.

  • The high-resolution, whole-genome technique helps detect the submicroscopic deletions/duplications called copy number variants (CNVs) in the chromosomes
  • CNVs are associated with a wide range of genetic disorders - Autism Spectrum disorders, autosomal disorders , X-linked Inheritance , UPD (Uniparental Disomy) and more.

CLINICAL UTILITY

note

Clinical diagnosis of cytogenetic abnormalities


differential

Differentiation between de novo(new unexplained mutations) and familial history of disorders


clarty

To clarify the clinical significance of copy number changes


influence

To influence the management of the conditions/disorders in a better way including lifestyle interventions.

ADVANTAGE OF CMA OVER OTHER CLINICAL PRACTICES:

detects

Detects copy-neutral loss of heterozygosity (CN-LOH) - 0.5 to 1 mb.

high-density

High density achieved by 750000 markers & SNP tagging

unbalanced

Unbalanced translocations, as low as 30 kb can be detected

low-levellow-level

Low level Mosaicism, upto 20% can be detected

The American College of Medical Genetics and Genomics (ACMG) recommends CMA as the first-line genetic test to detect the suspected chromosomal anomalies, developmental delay, intellectual disability, autism, and/or multiple congenital anomalies, and other known conditions caused due to cytogenetic abnormalities.

CMA IN POSTNATAL

BEHAVIOURAL

Autism Spectrum Disorder / Pervasive Developmental Disorder, Obsessive Compulsive Disorder.

developement

DEVELOPMENT

Fine Motor Delay, Gross Motor Delay, Speech Delay, Limb Anomalies, Polydactyly, Club Foot

cognative

COGNITIVE

Intellectual Disability, Learning Disability.

genitourinary

GENITOURINARY

Ambiguous Genitalia, Hydronephrosis, Kidney Malformation, Undescended Testis

craniofacial

CRANIOFACIAL

Cleft Lip/Palate, Dysmorphic Facial Features, Ear Malformation, Macro/Microcephaly

neurological

NEUROLOGICAL

Epilepsy/Seizures, Brain Anomaly


CMA is the first step to get the diagnosis you need for the effective management of genetic conditions and their risk of recurrence.

MAPMYGENOME - CMA OFFERINGS

Chromosomal Microarray genotyping

Chromosomal Microarray genotyping with Illumina 750K Bead chip optimized for efficient cytogenetic analysis.


high-density

High-density screening of 324 known cytogenetic regions commonly screened & used as hotspots for cytogenetic testing.


copy-neutral

Copy neutral loss of heterozygosity (Cn-LOH) region detected based on intensity & SNP genotype in order to screen for UPD (Uniparental Disomy) & autosomal recessive disorders.


copy-number

Copy Number Variations as small as 2.3kB CNV regions detected.


750000-dna

750000 markers covering ~9000 genes analyzed with emphasis on ~447 disease-associated genes.


genomic structure

495268 genomic structural variants researched from Database of Genomic Variants for better interpretation.


also-covers

Also covers: Pericenters and Telomeres | Sex Chromosomes | Pseudo Autosomal Region (PAR1 and PAR2) | Common Regions of Interest Associated with Known Syndromes

TEST SAMPLE REQUIREMENTS

extracted

EDTA Blood (2-3ml)

extracted

Extracted DNA samples (1µg - 2µg)

How Does Chromosomal MicroArray Work?



sample

Sample Collection

Your Doctor places a request for the test. The sample is tested for the susceptibility.

lab

Lab Processing

The sample processed on Illumina Global Screening Array Bead chip

analysis

Data Analysis

Your genetic sequence is subjected to extensive Cytogenetic analysis to extract your health information.

report

Report Generation

Our team generates a comprehensive report based on genetic findings, reviews the report, and shares it with your doctor via email.

Write Your Own Review
You're reviewing:Chromosomal Microarray (Postnatal)
Your Rating

Chromosomal MicroArray

1. Does this test provide confirmatory results?

2. Does this test carry any risk for the child?

3. What is the right time to get a CMA test done?

4. Why is CMA recommended over Karyotyping?