Toxexpress

জুন 04, 2026 Md. Zubair Ahmed

<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress® Program was a collaborative program with several large Pharma companies and Gene Logic. Of late, there has been interest in this program by several companies in the Chemical, Environmental, Tobacco and Cosmetic Industry. For those trying to evaluate this program this list of references may be very helpful to see how others have used this program effectively. <a href="http://www.genelogic.com/knowledge-suites/toxexpress-program" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">http://www.genelogic.com/knowledge-suites/toxexpress-program</a> <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2017</h3> <a href="https://www.sciencedirect.com/science/article/pii/B9780128036204000165" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Molecular Pathology: Applications in Nonclinical Drug Development</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">L Oyejide, OR Mendes, I Mikaelian - A Comprehensive Guide to Toxicology …, 2017 - Elsevier <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;padding:10pt 0pt 0pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2016</h3> <a href="https://patents.google.com/patent/US9353415B2/en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods for functional analysis of high-throughput experimental data and gene groups identified therefrom</a> <a href="https://scholar.google.com/citations?user=93CN07AAAAAJ&hl=en&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Y Nikolsky</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, A Bugrim, T Nikolskaya - US Patent 9,353,415, 2016 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">… Current analytical software and empirical gene expression reference databases include Iconix DrugMatrix and <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GeneLogic's<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">. This software has relatively low predictive power … <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GeneLogic<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, DB/commercial, rat, Affymetrix …   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 19pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2015</h3> <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-7pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2014</h3>   <a href="https://www.sciencedirect.com/science/article/pii/B978012397862200019X" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Bioinformatics methods for interpreting toxicogenomics data: the role of text-mining</a> <a href="https://scholar.google.com/citations?user=yCiOCgkAAAAJ&hl=en&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">KM Hettne</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, J Kleinjans, RH Stierum, A Boorsma… - … -Based Cellular Models, 2014 - Elsevier <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">… to infer toxicity about a new chemical entity via chemicals for which the toxicity is already known (Figure 6.3.1). A gene-expression profile is compared to reference gene-expression profiles collected in databases such as the commercial <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> (from <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GeneLogic<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">) [74] and …   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2013</h3> <a href="https://www.sciencedirect.com/science/article/pii/B9780123914965000107" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Gene logic and toxicogenomics biomarkers</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">WB Mattes - The Path from Biomarker Discovery to Regulatory …, 2013 - Elsevier<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">… effort [23]. The details in the <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">® database and ToxScreen™ models were indeed important, and were the matter for much discussion in TDMC meetings and among <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Gene<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Logic<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> scientists and statisticians. One relatively … <a href="https://www.sciencedirect.com/science/article/pii/S0041008X11000251" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century</a> <a href="https://scholar.google.com/citations?user=k01P1RwAAAAJ&hl=en&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">HM Mortensen</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, SY Euling - Toxicology and applied pharmacology, 2013 - Elsevier   <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[BOOK]<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> <a href="https://books.google.com/books?hl=en&lr=&id=LC7sCAAAQBAJ&oi=fnd&pg=PR9&dq=toxexpress+genelogic&ots=yD96lE0LRy&sig=hHlZgAgW9R5B923cgUALoD0xd10" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#660099;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#006621;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">T Inoue, WT Pennie - 2013 - books.google.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">… 49 Matthew Bartosiewicz and Alan Buckpitt The <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ToxExpress<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">" Module: Applying Gene Expression Data to Predictive Toxicology•• eeoe … Setagaya-ku, Tokyo 158-8501, Japan Mendrick, Donna L., Vice President, Toxicology Program, <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Gene<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Logic<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> Inc., 708 … dmendrick (@ <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">genelogic<span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#222222;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> … <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="https://scholar.google.com/scholar?cites=996638579551852652&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#660099;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 10</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> <a href="https://scholar.google.com/scholar?q=related:bFij94HF1A0J:scholar.google.com/&scioq=toxexpress+genelogic&hl=en&as_sdt=0,5&as_ylo=2013&as_yhi=2013" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#660099;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a> <a href="http://toxsci.oxfordjournals.org/content/127/1/1.short" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">I Rusyn, <a href="http://scholar.google.com/citations?user=ASLPu1cAAAAJ&hl=en&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">A Sedykh</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, Y Low, KZ Guyton… - Toxicological …, 2012 - Soc Toxicology... (2011) reported a similar outcome when gene expression data ... Evaluation System[http://toxico.nibio.go.jp/], Chemical Effects in Biological Systems Database [http://www.niehs.nih.gov/research/resources/databases/cebs/],ToxExpress [http://www.genelogic.com/knowledge ...     <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2011</h3> <a href="http://www.ingentaconnect.com/content/apl/emt/2011/00000007/00000003/art00003" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Quantitative knowledge-based analysis in compound safety assessment</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">S Bureeva… - Expert Opinion on Drug Metabolism …, 2011 - ingentaconnect.com. Two compa- nies, GeneLogic and Iconix, developed commercial databases of gene expression profiles and 'drug signatures' for dozens of toxicity end points and hundreds of drugs, known, respectively, as ToxExpress Ò Program [26] and DrugMatrix [18]. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">    <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2010</h3>   <a href="http://www.sciencedirect.com/science/article/pii/S1383574210000554" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">State-of-the-art genomics approaches in toxicology</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">P Van Hummelen… - Mutation Research/Reviews in Mutation …, 2010 - Elsevier... for hepatotoxicity based on raw microarray data within ToxExpress ® data base of Gene Logic. ...Japanese Toxicogenomics Project in which they developed a 112 gene classifier to ... GeneLogic's ToxExpress ® Program contains a database comprised of over 14,000 drug treated ...  <a href="http://books.google.co.in/books?hl=en&lr=&id=m0Pf5Qzu-4AC&oi=fnd&pg=PA284&dq=%22ToxExpress%22+Gene+Logic&ots=4ZOaIoYpQE&sig=G-DBc8LJqNvgVnAYpO0mpWwfKQ8" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">15 Toxicogenomic and pathway analysis</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">B Lu, Y Jiang… - Predictive Toxicology in Drug Safety, 2010 - books.google.com... In the commercial arena, GeneLogic's ToxExpress and Entelo's DrugMatrix are the two major … DrugMatrix also come from two main data- base vendors Genelogic and Entelos. ... toxicity15 DrugMatrix; 5 -day signatures predict 30-day nephrotoxicity10 Gene Logic ToxShield R&D ...  <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#000000;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] <a href="http://academicjournals.org/AJPP/PDF/pdf2010/November/Fokunang%20et%20al.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics revolution in the optimisation of pharmaceutical drug development and drug safety evaluations</a> <a href="http://academicjournals.org/AJPP/PDF/pdf2010/November/Fokunang%20et%20al.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from academicjournals.org</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">CN Fokunang, EA Tembe-Fokunang… - African Journal of …, 2010 - academicjournals.org ... Gaithersburg, MD, USA) has built a reference database called the ToxExpress™ Module (Wen … However, gene expression for certain genes might be switched on or off, rather ... Finally, toxicogenomics DB providers such as GeneLogic, CuraGen and Iconix supply software tools ... <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7817840&id=aCnYAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predicting hepatotoxicity using cell based assays</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">LC Mattheakis, JK Trautman, GP Solar… - US Patent …, 2010 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Med. Biol. 41:523-537, 1996. R. Pepperkok et al., "System for quantitation of gene expression in single cells by computerized microimaging: Application to c-fos expression after microinjection of anti-casein kinase II antibody", Experimental Cell Research 204:278-285, 1993. ... <a href="http://nopr.niscair.res.in/handle/123456789/7394" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Drug development from natural products: Exploiting synergistic effects</a> <a href="http://nopr.niscair.res.in/bitstream/123456789/7394/1/IJEB%2048(3)%20208-219.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from niscair.res.in</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">G Ulrich-Merzenich, D Panek, H Zeitler… - Indian journal of …, 2010 - nopr.niscair.res.in ... 200 validated gene signature sets Gene Logic www.genelogic.com ToxExpress™ ToxExpress™ reference data base predictive system with in in vivo+in vitro models. Extensive liver toxicity database. Exonhit www.exonhit.com ...   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2009</h3>   <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7590493&id=3rbIAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods for determining hepatotoxins</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">D Mendrick, M Porter, K Johnson, B Higgs… - US Patent …, 2009 - Google Patents ... DL, ToxExpress, FDA-DIA Pharmacogenomics Work- shop May 2002, (2002). Mendrick, D., "Discovery of Relevant biomarkers for Nonclinical and Clinical Applications," American College of Toxicology Mtg. Nov. 8, 2004, (2004). Mendrick, D., "Rold of Gene Expression Studies ...  <a href="http://www.sciencedirect.com/science/article/pii/S0378427408012368" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Similar compounds searching system by using the gene expression microarray database</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">H Toyoshiba, H Sawada, I Naeshiro… - Toxicology letters, 2009 - Elsevier <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Tong et al., 2003), ArrayExpress at the EBI (Parkinson et al., 2007), the Toxicogenomics Project (TGP) (Takashima et al., 2006), Iconix DrugMatrix, the GeneLogic ToxExpress and BioExpress, and the NCBI microarray data repository Gene Expression Omnibus (GEO) (www.ncbi ...  <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#000000;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] <a href="http://www.ibc7.org/data_file/submission/200910/IBC2.000087.01_print.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics and Cell-based Assays for Toxicology</a> <a href="http://www.ibc7.org/data_file/submission/200910/IBC2.000087.01_print.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from ibc7.org</a> <a href="http://scholar.google.co.in/citations?hl=en&user=CXtPbooAAAAJ&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">W Tong</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, <a href="http://scholar.google.co.in/citations?hl=en&user=z_0okvoAAAAJ&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">H Fang</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">… - IBC, 2009 - ibc7.org <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... For example, ToxExpress® (http://www.genelogic.com/) and DrugMatrix® (http://www.iconixbiosciences.com/) are two of the most comprehensive reference databases available, devel- oped by Gene Logic and Iconix, respectively. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.springerlink.com/index/K312518V8U6W7795.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics Application to Oncology Drug Development</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">L Calzolai… - … in Anticancer Drug Development and Clinical …, 2009 - Springer ... ToxExpress Gene Logic Inc.: ToxExpress Module www.genelogic.com PTS CuraGen Corporation: Predictive www.curagen.com/rnd/pts.asp Toxicogenomic Screen GeneMatrix Iconix Biosciences, Inc.: GeneMatrix www.iconixbiosciences.com ...   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2008</h3> <a href="http://onlinelibrary.wiley.com/doi/10.1002/9780470699638.ch6/summary" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Key Aspects of Toxicogenomic Data Analysis and Interpretation as a Safety Assessment Tool to Identify and Understand Drug‐Induced Toxicity</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">A Vladimirova… - Toxicogenomics, 2008 - Wiley Online Library <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... These include databases from commercial sources, such as Gene- Logic's ToxExpress R с System (Castle et al., 2002) (http://www.genelogic.com/genomics/ toxexpress/system.cfm),and Entelos (formerly Iconix Biosciences) DrugMatrix R с (http:// ... <a href="http://www.sciencedirect.com/science/article/pii/s0041-008x(08)00050-1" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">MGL Elferink, P Olinga, AL Draaisma… - Toxicology and applied …, 2008 - Elsevier... TM (Suite v1.0 and the liver V toxicity prediction model)(Gene Logic, an Ocimum ... models to assess the potential for human hepatotoxicity based on rat gene expression data. ... Affymetrix CEL files for the appropriate treated samples and controls (GeneLogic, www.genelogic.com ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">SA Barros… - METHODS IN MOLECULAR BIOLOGY-CLIFTON …, 2008 - Springer... This chapter describes our internal efforts to develop and evaluate predictive in vitro and in vivo toxicogenomic models for hepatotoxicity based on the raw microarray data within the ToxExpress® database (Gene Logic, Inc., Gaithersburg, MD), with the goal of leveraging this ...  <a href="http://www.springerlink.com/index/WMQ6U27031086318.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics and classic toxicology: how to improve prediction and mechanistic understanding of human toxicity</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick - … IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-, 2008 - Springer <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Genomic analysis can detect such events as shown in Fig. 3 and Fig. 4. Studies in GeneLogic's (Gaithersburg, MD) ToxExpress® database were used for the analysis. InFig. ... A study was performed using data in Gene Logic's ToxExpress database. ...  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7426441&id=nJ6tAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods for determining renal toxins</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">D Mendrick, M Porter, K Johnson, B Higgs… - US Patent …, 2008 - Google Patents... CI. G06F 19/00 (2006.01) The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a knownrenal toxin. ... Kawamoto, etal., Gene, 174:151-158 (1996). ... <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7447594&id=6hawAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Molecular cardiotoxicology modeling</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick, MW Porter, KR Johnson… - US Patent …, 2008 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Pharmacol, 45: 2289-2294 (1993). (Continued) Primary Examiner—Carolyn L. Smith (74) Attorney, Agent, or Firm—Cooley Godward Kronish LLP (57) ABSTRACT The present invention is based on the elucidation of the global changes in gene expression and the identification ... <a href="http://scholar.google.co.in/scholar?cites=3363623139978282898&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 1</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:koewsGz9rS4J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=3363623139978282898&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://onlinelibrary.wiley.com/doi/10.1002/9780470516751.ch17/summary" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Application of Toxicogenomics in Predicting Hepatotoxicity–Potentials and Challenges</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">W Lin, G Shen, TO Khor… - Hepatotoxicity - Wiley Online Library There are some commercial companies, such as 'GeneLogic ToxExpress' and 'CuraGen', which provide commercially available toxicogenomic databases, aiming to improve the prediction of hep- atotoxicants and human-specific toxicants through gene expression profile ... <a href="http://onlinelibrary.wiley.com/doi/10.1002/9780470699638.ch14/summary" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">L Suter - Toxicogenomics, 2008 - Wiley Online Library Toxicogenomics databases such as DrugMatrix R с by Iconix/Entelos (Fielden and Kolaja, 2006) and ToxExpress R с by Genelogic, and several ... Experimental evidence using gene expression profiling of monkeys treated with ciprofibrate, a PPAR α agonist, revealed clear species ...  <a href="http://www.springerlink.com/index/T303132146402H85.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">From Pharmacogenomics to Translational Biomarkers</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick - … IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-, 2008 - Springer <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Examination of Kim-1 in human renal diseases was performed using the BioExpress® database at Gene Logic (Gaithersburg, MD). ... Studies from the ToxExpress database were selected to examine the time course of gene expression change and the results from three ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.springerlink.com/index/w34u513v2344p372.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">In Vivo Predictive Toxicogenomics</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">MW Porter - … IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA-, 2008 - Springer <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... For commercial predictive service providers such as Gene Logic Inc. (Gaithersburg, MD, USA) and Iconix Pharmaceuticals Inc. ... There is no single way to treat multiple time point data in building models. Gene Logic has attempted to build models by two methods. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.futuremedicine.com/doi/pdf/10.2217/14622416.9.1.35" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Pathway analysis tools and toxicogenomics reference databases for risk assessment</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">B Ganter, N Zidek, PR Hewitt, D Müller… - …, 2008 - Future Medicine <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... database of the NIH/NIEHS [64,65,123], ArrayTrack from the FDA/NCTR [66,124], ArrayExpress at the EBI [67,125] and the NCBI microarray data repository Gene Expression Omnibus (GEO) [126]. The commercial databases include GeneLogic's ToxExpress ® System [22,127 ... <a href="http://scholar.google.co.in/scholar?cites=17772151284379607063&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 29</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:F-Dyp25do_YJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/2A/3D/RN221869318.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=17772151284379607063&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2007</h3> <a href="http://www.futuremedicine.com/doi/pdf/10.2217/17520363.1.2.319" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">From the bench to the clinic and back again: translational biomarker discovery using in silico mining of pharmacogenomic data</a> <a href="http://www.future-science-group.com/_img/pics/Mendrick___Daniels_(2007).pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from future-science-group.com</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick… - Biomarkers, 2007 - Future Medicine <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... translational biomarker. Using Gene Logic's BioExpress and ToxExpress databases,the expression of FETUB in multiple species was explored. In Figure 4, the expression of FETUB in various liver diseases in humans is shown. The ... <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP12520441&id=HurUAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">NOVEL METHODS FOR FUNCTIONAL ANALYSIS OF HIGH-THROUGHPUT EXPERIMENTAL DATA AND GENE GROUPS IDENTIFIED THEREFROM</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Y Nikolsky, A Bugrim… - US Patent App. 12/520,441, 2007 - Google Patents ... a microarray platform. Current analytical software and empirical gene expression reference databases include Iconix DrugMatrix and GeneLogic's ToxExpress. This software has relatively low predictive power. However, this ... <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7251642&id=-MSAAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Analysis engine and work space manager for use with gene expression data</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">E Szeto - US Patent 7,251,642, 2007 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... 31, 2007 (56) ANALYSIS ENGINE AND WORK SPACE MANAGER FOR USE WITH GENE EXPRESSION DATA Inventor: Ernest Szeto, Berkeley, CA (US) Assignee: Gene Logic Inc.,Gaithersburg, MD (US) Notice: Subject to any disclaimer, the term of this patent is extended or ... <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPAT7235353&id=rWGAAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predicting hepatotoxicity using cell based assays</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">LC Mattheakis, JK Trautman, GP Solar… - US Patent …, 2007 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Med. Biol. 41:523-537, 1996. R. Pepperkok et al., "System for quantitation of gene expression in single cells by computerized microimaging: Application to c-fos expression after microinjection of anti-casein kinase II antibody", Experimental Cell Research 204:278-285, 1993. ...   <a href="http://www.ingentaconnect.com/content/adis/ipm/2007/00000021/00000006/art00007" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Incorporating genome-based technologies into toxicology and safety assessments for drug discovery and development</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">LG Yengi - International Journal of Pharmaceutical Medicine, 2007 - ingentaconnect.com... field was Gene Logic Inc. (Gaithersburg, throughput screening and the human genome project, which made MD, USA) which, in partnership with a group of pharmaceutical it possible for newly sequenced clones and transcripts to be easily companies, developed ToxExpress® 1 ...     <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2006</h3>   <a href="http://informahealthcare.com/doi/abs/10.1080/00498250600861801" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predictive models of hepatotoxicity using gene expression data from primary rat hepatocytes</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">L Hultin-Rosenberg, S Jagannathan… - …, 2006 - informahealthcare.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Expression profiles Expression profiles were obtained by performing directed queries on the ToxExpress database from Gene Logic (http://www.genelogic.com; Castle et al. 2002). Profiles were obtained from treatments of hepatocytes ... <a href="http://scholar.google.co.in/scholar?cites=36108869311677323&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 19</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:i0OQSNNIgAAJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/0E/0D/RN200645206.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=36108869311677323&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 5 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.futuremedicine.com/doi/pdf/10.2217/14622416.7.7.1003" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics strategies for predicting drug toxicity</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">R Martin, D Rose, K Yu… - Pharmacogenomics, 2006 - Future Medicine... Samples for the two knowledge bases were subsets of those available from the ToxExpress ® database (Gene Logic, Inc., MD, USA). The in vitro knowledgebase consisted of data derived from rat primary hepatocytes, while ... <a href="http://scholar.google.co.in/scholar?cites=1718390008860914839&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 17</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:lzS8z5vy2BcJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/0F/10/RN207874770.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=1718390008860914839&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[CITATION] The ToxExpress™ Module*: applying gene expression data to predictive toxicology <a href="http://www.sciencedirect.com/science/article/pii/S0169409X06001700" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Application of data mining approaches to drug delivery</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">S Ekins, J Shimada… - Advanced drug delivery reviews, 2006 - Elsevier <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... several hundred marketed drugs and toxicants using different array platforms (the Iconix Drug Matrix™ [60], GeneLogic ToxExpress™ [61] and ... connected with molecule bioactivity databasessuch as BioPrint, which would combine molecular interactions at the gene level with ... <a href="http://scholar.google.co.in/scholar?cites=8881455621161486742&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 21</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:lgm629REQXsJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=8881455621161486742&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 7 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://informahealthcare.com/doi/abs/10.1080/15376520600558317" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics and cross-species biomarker discovery: applications in drug discovery and safety assessment</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">MS Orr - Toxicology Mechanisms and Methods, 2006 - informahealthcare.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... At Gene Logic Inc., Affymetrix GeneChips® microarrays were used to identify dysregulated secreted genes in human or rat samples. Comparisons of the dysregulated genes identified in either the human (BioExpress® database) or rat studies (ToxExpress® database) were ... <a href="http://scholar.google.co.in/scholar?cites=16692264709517140154&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 4</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:uuCOW1DWpucJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/08/5E/RN183985693.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=16692264709517140154&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP12064933&id=yw_UAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">MOLECULAR CARDIOTOXICOLOGY MODELING</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick… - US Patent App. 12/064,933, 2006 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... CI. C12Q 1/68 (2006.01) (52) US CI 435/6 (57) ABSTRACT The present invention includes methods of predicting car- diotoxicity of test agents and methods of generating car- diotoxicity prediction models using algorithms for analyzing quantitative gene expression information. ... <a href="http://scholar.google.co.in/scholar?cluster=14944732393695453675&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 2 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.futuremedicine.com/doi/pdf/10.2217/14622416.7.7.1025" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix® database</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">B Ganter, RD Snyder, DN Halbert… - Pharmacogenomics, 2006 - Future Medicine... Since the most effective application of toxicogenomics requires generation of high content gene expression data on large numbers of reference compounds, and therefore ... Commercial toxicogenomic databases include GeneLogic's (MD, USA) ToxExpress™ Module [47,205 ... <a href="http://scholar.google.co.in/scholar?cites=14551518951482373301&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 22</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:tbR4nWNh8ckJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/25/5D/RN207874794.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=14551518951482373301&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 5 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP11375597&id=uU-ZAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predicting hepatotoxicity using cell based assays</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">LC Mattheakis, JK Trautman, GP Solar… - US Patent App. 11/ …, 2006 - Google Patents... See "Serious liver injury: leading reasons for drug removals, restrictions" www.fda.gov/fdac/features/ 2001/301_liver.html; and ToxExpress™ Application Note, GeneExpress ToxExpressPredictive System™, Gene Logic, Gaithersburg, Md. (2002). ... <a href="http://informahealthcare.com/doi/abs/10.1080/00498250600861793" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Tissue and species distribution of the glutathione pathway transcriptome</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">WB Mattes, KK Daniels, M Summan, ZA Xu… - …, 2006 - informahealthcare.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... arrays. Rat and canine gene expression data are resident in Gene Logic's ToxExpress® System Database, whereas mouse gene expression data are found within Gene Logic's BioExpress® System Database. Affymetrix probesets ... <a href="http://scholar.google.co.in/scholar?cites=10274682775099491776&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 9</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:wEWh3YsBl44J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/38/4C/RN200645192.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=10274682775099491776&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 6 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2005</h3>   <a href="http://informahealthcare.com/doi/abs/10.1081/CLT-50407" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">The use of toxicogenomic data in risk assessment: a regulatory perspective</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">VSW Chan, MD Theilade - Clinical Toxicology, 2005 - informahealthcare.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... GeneLogic ToxExpress is a consortium of more than seven pharmaceutical companies that examines samples from rats, dogs, and humans using microarray and traditional toxicity assessment methods. The group aims to collect data on gene expression changes ... <a href="http://scholar.google.co.in/scholar?cites=1540568902575569328&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 12</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:sLkHLkEzYRUJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/0F/29/RN171459927.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=1540568902575569328&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP11547759&id=iElgAQAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Hepatotoxicity Molecular Models</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">M Porter, B Higgs, D Mendrick… - US Patent App. 11/ …, 2005 - Google Patents... Each elec- tronic copy of the Sequence Listing was created on Mar. 28, 2005 with a file size of 5995 KB. The file names are as follows: Copy 1—gene logic 5134-wo.txt; Copy 2—gene logic 5134-wo.txt; Copy 3—gene logic 5134-wo.txt.; and CRF—gene logic 5134-wo.txt. ...  <a href="http://www.sciencedirect.com/science/article/pii/S0165614705000519" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Techniques: application of systems biology to absorption, distribution, metabolism, excretion and toxicity</a> <a href="http://www.bgsc.acad.bg/articles/library/In%20Silico%20Drug%20%20Design/ADMET_Soft.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from acad.bg</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">S Ekins, Y Nikolsky… - Trends in pharmacological sciences, 2005 - Elsevier <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Several companies market content databases of gene-expression profiles, histopathology,multi-parameter clinical chemistry tests and ... These include Iconix (Drug Matrix™;http://www.iconixpharm.com/), GeneLogic (ToxExpress™; http://www.genelogic.com/) [55], ... <a href="http://scholar.google.co.in/scholar?cites=14179693325741340070&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 124</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:pjXK2PNjyMQJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=14179693325741340070&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 18 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.sciencedirect.com/science/article/pii/s0027-5107(05)00141-7" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics in the pharmaceutical industry: Hollow promises or real benefit?</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">A Lühe, L Suter, S Ruepp, T Singer… - Mutation Research/ …, 2005 - Elsevier... In addition to the non-commercial resources, commercial providers, such as Gene Logic,Inc. (ToxExpress ® ) or Iconix Pharmaceuticals, Inc. (DrugMatrix ® ) offer comprehensive instruments for assessment of the toxic potential of a compound. ... <a href="http://scholar.google.co.in/scholar?cites=5677544465438509118&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 49</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:PojyQpywyk4J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=5677544465438509118&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 6 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.ingentaconnect.com/content/ben/cmm/2005/00000005/00000001/art00007" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">The role of transcriptome analysis in pre-clinical toxicology</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GH Searfoss, TP Ryan… - Current Molecular Medicine, 2005 - ingentaconnect.com... Prediction of 10 different liver toxicities. Gene Logic www.genelogic.com ToxExpress™Gaithersburg, MD ToxExpress™ reference database predictive system with in vivo and in vitromodels. Extensive liver toxicity database. Multifaceted tools and services.  <a href="http://scholar.google.co.in/scholar?cites=14703150901438806471&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 32</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:x3k5H9gVDMwJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=14703150901438806471&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 7 versions</a> <a href="http://bfg.oxfordjournals.org/content/3/4/303.short" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Expression genomics and drug development: towards predictive pharmacology</a> <a href="http://bfg.oxfordjournals.org/content/3/4/303.full.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from oxfordjournals.org</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ET Liu - Briefings in functional genomics & proteomics, 2005 - bfg.oxfordjournals.org... Keywords: transcription, cDNAs, expression signatures, gene regulation, drug effects ... It demonstrated a hierarchy of transcriptional impact, with cell lineage making a greater impact than biochemical pathways, and, in turn, greater than individual gene effects. ... <a href="http://scholar.google.co.in/scholar?cites=15819716311959609777&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 11</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:sSHOVSvsitsJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=15819716311959609777&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 8 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://bioinformatics.oxfordjournals.org/content/21/10/2145.short" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Prediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates</a> <a href="http://bioinformatics.oxfordjournals.org/content/21/10/2145.full" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[HTML] from oxfordjournals.org</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">SÓ Jónsdóttir, FS Jørgensen… - Bioinformatics, 2005 - Oxford Univ Press <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... The ToxExpress Reference Database is a toxicogenomic database, which contains gene expression profiles from known toxicants. This database is built on in vivo and in vitro studies of exposure to toxicants, and around 110 compounds have been profiled. ... <a href="http://scholar.google.co.in/scholar?cites=4183123624085506767&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 54</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:z0op4cVwDToJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=4183123624085506767&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 15 versions</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">   <a href="http://tpx.sagepub.com/content/33/1/185.short" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">P1 Altered Expression of Gene Products Involved as a Complex in the Endogenous Hepatocarcinogenesis of Rats Fed a Choline-Deficient, L-Amino Acid-Defined …</a> <a href="http://tpx.sagepub.com/content/33/1/185.full" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[HTML] from sagepub.com</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">D Nakae, F Uematsu, Y Hatanaka… - Toxicologic …, 2005 - tpx.sagepub.com... P1 Altered Expression of Gene Products Involved as a Complex in the Endogenous <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Hepatocarcinogenesis of Rats Fed a Choline-Deficient, L-Amino Acid-Defined Diet. ... P11 Gene <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Expression in Regenerating Rat Liver Following Partial Hepatectomy: A Detailed Time Course. ... <a href="http://scholar.google.co.in/scholar?q=related:n28tMVzKZ7MJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a> <a href="http://www.sciencedirect.com/science/article/pii/S0041008X04005563" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile …</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">N Fletcher, D Wahlström, R Lundberg… - Toxicology and applied …, 2005 - Elsevier ... Clinical chemistry and pathological examination was carried out at Gene Logic Inc. ... Dose selection was designed to encompass the dose at which gene changes were observed using microarray analyses. ... Data are contained within GeneLogic's Toxexpress database. ... <a href="http://scholar.google.co.in/scholar?cites=9081052801973300279&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 86</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:Nywv8GhhBn4J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=9081052801973300279&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 5 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2004</h3> <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10948635&id=r8CVAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods for enhancing gene expression analysis</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">U Scherf, GD Hoke, DJ Wilson… - US Patent App. 10/ …, 2004 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... MD (US); Daniel J. Wilson, Mississauga (CA); Debra A. Barnes, Frederick, MD (US)Correspondence Address: MORGAN LEWIS & BOCKIUS LLP 1111 PENNSYLVANIA AVENUE NW WASHINGTON, DC 20004 (US) (73) Assignee: Gene Logic, Inc., Gaithersburg, MD (21) Appl. ... <a href="http://ajprenal.physiology.org/content/286/4/F702.short" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Gene expression alterations during HGF-induced dedifferentiation of a renal tubular epithelial cell line (MDCK) using a novel canine DNA microarray</a> <a href="http://ajprenal.physiology.org/content/286/4/F702.full" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[HTML] from physiology.org</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DF Balkovetz, ER Gerrard Jr, S Li… - American Journal of …, 2004 - Am Physiological Soc <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... The cRNA products were fragmented to 200 nucleotides or less, heated at 99°C for 5 min, and hybridized for 16 h at 45°C to the ToxExpress GeneChip Canine Array, which was developed as a custom array by Gene Logic and Pfizer, using Affymetrix standard design ... <a href="http://scholar.google.co.in/scholar?cites=8831978514782340039&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 22</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:x8N7Vap9kXoJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://direct.bl.uk/research/1E/4E/RN148550436.html?source=googlescholar" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">BL Direct</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=8831978514782340039&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 5 versions</a> <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10541937&id=pH-gAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Molecular cardiotoxicology modeling</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick, MW Porter, KR Johnson… - US Patent App. 10/ …, 2004 - Google Patents... CI. C12Q 1/68 G06F 19/00 (52) US CI (57) (2006.01) (2006.01) ABSTRACT 435/6; 702/20 The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#000000;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] <a href="http://ww.sumitomo-chem.co.jp/english/rd/report/theses/docs/20040105_7g4.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Overview of Current State of Affairs and Perspectives on Toxicogenomics.</a> <a href="http://ww.sumitomo-chem.co.jp/english/rd/report/theses/docs/20040105_7g4.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from sumitomo-chem.co.jp</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">K SUMIDA… - ww.sumitomo-chem.co.jp <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... Treatment Rat Hepatocyte (Human, Rat) Bioinformatics CuraGen Gene Logic Iconix Company <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GeneCalling® Affymetrix GeneChip Amersham CodeLink Gene Expression Platform Predictive <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics Screen (PTS) ToxExpress/ ToxSuite/ ToxScreen DrugMatrix ... <a href="http://scholar.google.co.in/scholar?q=related:h1ECCCY-P9gJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.googleusercontent.com/scholar?q=cache:h1ECCCY-P9gJ:scholar.google.com/+%22ToxExpress%22+Gene+Logic&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">View as HTML</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=15582241568789254535&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 4 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10515373&id=Wb6gAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Primary rat hepatocyte toxicity modeling</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">D Mendrick, M Porter, K Johnson… - US Patent App. 10/ …, 2004 - Google Patents <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">... S. Orr, Gaithersburg, MD (US); Michael Elashoff, Gaithersburg, MD (US) Correspondence Address: COOLEY GODWARD LLP THE BROWN BUILDING - 875 15TH STREET, NW SUITE 800 WASHINGTON, DC 20005-2221 (US) (73) Assignee: Gene Logic Inc., Gaithersburg, MD .. <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10580423&id=rlWwAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods For Molecular Toxicology Modeling</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">JC Diggans… - US Patent App. 10/580,423, 2004 - Google Patents... In a preferred embodiment, the database is a ToxExpress® or BioExpress® database marketed by Gene Logic Inc., Gaithersburg, Md. [0061] The databases of the invention may be linked to an outside or external database such as GenBank (www ncbi. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#000000;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[BOOK] <a href="http://books.google.co.in/books?hl=en&lr=&id=gt8JNQfpnMIC&oi=fnd&pg=PR15&dq=%22ToxExpress%22+Gene+Logic&ots=RTBmbCWbIy&sig=lc6N446n1BpU10p3Y2N-Ce3T6jk" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Analyzing microarray gene expression data</a> <a href="http://scholar.google.co.in/citations?hl=en&user=1bYCHtsAAAAJ&oi=sra" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">GJ McLachlan</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">, KA Do… - 2004 - books.google.com <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Page 1. Analyzing Microarray Gene Expression Data Page 2. This Page Intentionally Left Blank Page 3. Analyzing Microarray Gene Expression Data Page 4. WILEY SERIES IN PROBABILITY AND STATISTICS Established ... <a href="http://scholar.google.co.in/scholar?cites=11266872510390202030&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 228</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:ru5rj9r4W5wJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=11266872510390202030&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 14 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2003</h3> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[CITATION] An introduction to toxicogenomics <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">ME Burczynski - 2003 - Informa HealthCare <a href="http://scholar.google.co.in/scholar?cites=12117814874704232735&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 10</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:H8Gw9GwgK6gJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=12117814874704232735&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 5 versions</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_article_pr?p_JournalId=3&p_RefId=376&p_IsPs=Y&p_ispdf=N" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics takes center stage</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">J Lehmann - Drug News Perspect, 2003 - journals.prous.com... Standardization of experimental methods was and continues to be pushed to the extreme limit to optimize precision and reproducibility in the ToxExpress project led by Gene Logic. ... URLs cited. Society of Toxicology: www.toxicology.org. Gene Logic: www.genelogic.com. ... <a href="http://scholar.google.co.in/scholar?cites=6544062081090971161&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 2</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:GeaHc8ot0VoJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=6544062081090971161&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 3 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[CITATION] 12 Predictive Toxicogenomics <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">MW Porter, AL Castle, MS Orr… - An introduction to …, 2003 - Informa HealthCare <a href="http://www.springerlink.com/index/JM200Q41712RNQ75.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predictive toxicogenomics in preclinical discovery</a> <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10719988&id=Q8uUAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Predicting hepatotoxicity using cell based assays</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">LC Mattheakis, JK Trautman, GP Solar… - US Patent App. 10/ …, 2003 - Google Patents... See "Serious liver injury: leading reasons for drug removals, restrictions" <a href="http://www.fda.gov/fdac/" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">www.fda.gov/fdac/</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> features/ 2001/301_liver.html; and ToxExpress™ Application Note, GeneExpress ToxExpress Predictive System™, Gene Logic, Gaithersburg, Md. (2002).  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10515325&id=dJ-BAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Molecular nephrotoxicology modeling</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick, MW Porter, KR Johnson… - US Patent App. 10/ …, 2003 - Google Patents... CI. G06F 19/00 (2006.01) (52) US CI 702/20 (57) ABSTRACT The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. ...   <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> [CITATION] The future of Toxicogenomics <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">JC Rockett - An introduction to toxicogenomics, 2003 - Informa HealthCare <a href="http://scholar.google.co.in/scholar?cites=2034345156428000285&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 1</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:HWxtLyRyOxwJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=2034345156428000285&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 2 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10620765&id=PnCJAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Nucleic acid detection assay control genes</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">A Castle, B Higgs, M Elashoff… - US Patent App. 10/620,765, 2003 - Google Patents... Available databases include, but are not limited to, the Gene Logic ToxExpress® database, the Gene Expression Omni- bus gene expression and hybridization array repository available through NCBI (www.ncbi.nlm.nih.gov/entrez) and the SAGE™ gene expression database. ... <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">DL Mendrick - Toxicogenomics, 2003 - Springer Verlag <a href="http://scholar.google.co.in/scholar?q=related:5OQPtudDRG8J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10633306&id=xoiVAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Methods for classification of biological data</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">AL Castle, MR Elashoff, KR Johnson… - US Patent App. 10/ …, 2003 - Google Patents... Gaithersburg, MD (US); Kory R. Johnson, Gaithersburg, MD (US); Mark W. Porter, Gaithersburg,MD (US) Correspondence Address: MORGAN LEWIS & BOCKIUS LLP 1111 PENNSYLVANIA AVENUE NW WASHINGTON, DC 20004 (US) (73) Assignee: Gene Logic,  <a href="http://scholar.google.co.in/scholar?cites=6430105628048568137&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 5</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:SS8TJABTPFkJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=6430105628048568137&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 2 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">    <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2002</h3> <a href="http://www.sciencedirect.com/science/article/pii/S1359644602023279" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxicogenomics: a new revolution in drug safety</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">AL Castle, MP Carver… - Drug discovery today, 2002 - Elsevier ... The combination of READS™ and ToxExpress™ (Gene Logic) and GeneChip® (Affymetrix, Santa Clara, CA, USA) enables the detection of both novel and known genes that respond to toxicants, as well as validation of interesting genes using Q-RT-PCR. Predictive toxicology. ... <a href="http://scholar.google.co.in/scholar?cites=6589108432170346567&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 63</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:R2gLXjU3cVsJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=6589108432170346567&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 6 versions</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10090144&id=qcSFAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">System and method for managing gene expression data</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">V Markowitz, T Topaloglou… - US Patent App. 10/ …, 2002 - Google Patents ... 11,2003 (54) SYSTEM AND METHOD FOR MANAGING GENE EXPRESSION DATA (76) Inventors:Victor Markowitz, Albany, CA (US); Thodoros Topaloglou, Menlo Park, CA (US); Kevin McLoughlin, Oakland, CA (US); John Campbell, Gaithersburg, MD (US); Dmitry Krylov ... <a href="http://www.sciencedirect.com/science/article/pii/S1359644602024108" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Applications of antisense and siRNAs during preclinical drug development</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">JD Thompson - Drug discovery today, 2002 - Elsevier... affymetrix.com). Libraries of drug profiles from mammalian cells are also commercially available from, for example, DrugMatrix (Incyte Genomics, <a href="http://www.incyte.com" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">http://www.incyte.com</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">) and ToxExpress (Gene Logic, http://www.genelogic.com). In ... <a href="http://scholar.google.co.in/scholar?cites=12571871059833147575&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 61</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:t1Beyx5CeK4J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=12571871059833147575&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 7 versions</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">  <a href="http://www.google.co.in/patents?hl=en&lr=&vid=USPATAPP10096645&id=8kakAAAAEBAJ&oi=fnd&dq=%22ToxExpress%22+Gene+Logic&printsec=abstract" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">System and method for retrieving and using gene expression data from multiple sources</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">V Markowitz, T Topaloglou… - US Patent App. 10/096,645, 2002 - Google Patents... 9,2003 (54) SYSTEM AND METHOD FOR RETRIEVING AND USING GENE EXPRESSION DATA FROM MULTIPLE SOURCES (76) Inventors: Victor Markowitz, Albany, CA (US); Thodoros Topaloglou, Menlo Park, CA (US); I-Min Amy Chen, El Cerrito, CA (US)  <a href="http://scholar.google.co.in/scholar?cites=14480694574727815537&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 42</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:ceGTY_7C9cgJ:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=14480694574727815537&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 2 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2001</h3>   <a href="http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=974413" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Applying data warehouse concepts to gene expression data management</a> <a href="http://iec01.mie.utoronto.ca/~thodoros/courses/mie1511/docs/BIBE01.pdf" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[PDF] from utoronto.ca</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">VM Markowitz… - … and Bioengineering Conference …, 2001 - ieeexplore.ieee.org... GeneExpress products are available as DataSuites, such as BioExpress and ToxExpress,which contain data on disease or tissue specific samples (see http://www.genelogic.com/gexpress ...GeneExpress is notable for its size: it includes gene expression data on thousands of ... <a href="http://scholar.google.co.in/scholar?cites=18283863952640533915&as_sdt=2005&sciodt=0,5&hl=en" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Cited by 14</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?q=related:m2W1kmRVvf0J:scholar.google.com/&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Related articles</a><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;"> - <a href="http://scholar.google.co.in/scholar?cluster=18283863952640533915&hl=en&as_sdt=0,5" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">All 7 versions</a>   <h3 dir="ltr" style="line-height:2.000769230769231;text-align: justify;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:12pt 0pt 19pt 0pt;"><span style="font-size:15pt;font-family:Montserrat,sans-serif;color:#1a0dab;background-color:transparent;font-weight:700;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">2000</h3> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#000000;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[HTML] <a href="http://www.f1000scientist.com/article/display/11645/" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">Toxico-Logic</a> <a href="http://www.f1000scientist.com/article/display/11645/" style="text-decoration:none;"><span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#1155cc;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:underline;-webkit-text-decoration-skip:none;text-decoration-skip-ink:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">[HTML] from f1000scientist.com</a> <span style="font-size:10pt;font-family:Montserrat,sans-serif;color:#777777;background-color:transparent;font-weight:600;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;white-space:pre-wrap;">A Francis - The Scientist, 2000 - f1000scientist.com ... Clontech 800-662-2566 www.clontech.com. Gene Logic 301-987-1700 www.genelogic.com. Incyte 877-746-2983 www.incyte.com. ... 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