Expecting a baby? Congratulations! Along with all the joy and excitement, pregnancy also brings important choices—especially when it comes to prenatal genetic screening.
One big question many expecting parents have today is:
Should I go for an NIPT test or stick with traditional prenatal testing?
Let’s simplify this for you.
What is Prenatal Genetic Screening?
Prenatal genetic screening refers to tests done during pregnancy to find out if the baby is at risk for certain genetic conditions or birth defects. These screenings don’t give a diagnosis—they only tell you the likelihood that something might be wrong.
What is an NIPT Test?
NIPT stands for Non-Invasive Prenatal Testing. It’s a fetal DNA test that checks for certain chromosomal conditions using a simple blood sample from the mother.
What does it detect?
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Down syndrome (Trisomy 21)
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Edwards syndrome (Trisomy 18)
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Patau syndrome (Trisomy 13)
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Sex chromosome abnormalities (like Turner or Klinefelter syndrome)
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Sometimes even the baby’s gender
What are Traditional Prenatal Tests?
These include tests like:
First Trimester Screening
This is a combination of:
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Blood tests
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Nuchal translucency ultrasound (measures fluid at the back of baby’s neck)
Triple or Quad Screening (Second Trimester)
These blood tests screen for:
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Neural tube defects
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Trisomy 21 and 18
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Hormone levels that may indicate issues
Invasive Diagnostic Tests
If screenings show high risk, these are sometimes suggested:
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Chorionic Villus Sampling (CVS) – done around 10–13 weeks
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Amniocentesis – done around 15–20 weeks
These carry a small risk of miscarriage because they involve collecting fluid or tissue from around the baby.
Key Differences: NIPT vs Traditional Prenatal Tests
| Feature | NIPT | Traditional Screening |
|---|---|---|
| Type | Non-invasive blood test | Blood test + ultrasound |
| Timing | From 10 weeks | First trimester (11-14 weeks), second trimester (15-22 weeks) |
| Accuracy | >99% for Down syndrome | ~85% for Down syndrome |
| Risk to baby | None | None (for screening) |
| Detects | Chromosomal conditions | Chromosomal + neural tube defects |
| Invasive follow-up needed? | Only if result is high-risk | Often, if result is high-risk |
| NIPT test price | Higher | Lower or covered by insurance |
What’s the NIPT Test Price?
The NIPT test price varies depending on the lab and country. In India, it typically ranges from ₹15000. Some advanced panels may cost more, especially if additional chromosomal or microdeletion testing is included.
Insurance coverage also varies. Always check with your provider before booking.
Why More Parents Are Choosing NIPT
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Higher Accuracy – Fewer false positives means less stress
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Earlier Testing – Get peace of mind as early as 10 weeks
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No Risk – Since it’s a simple blood test, there’s no harm to the baby
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Gender Reveal – Some parents love knowing the baby’s gender early (if they choose to)
When Should You Go for NIPT?
NIPT is recommended for all pregnant women, but especially if:
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You’re 35 years or older
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There’s a family history of genetic disorders
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You had abnormal results in traditional tests
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You had a previous pregnancy with chromosomal abnormalities
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You want earlier and more accurate screening
Can I Do Both NIPT and Traditional Tests?
Yes. Some doctors recommend combining NIPT with ultrasound for a comprehensive view of baby’s health. For example:
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NIPT plus First Trimester Scan gives you genetic and structural insights
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NIPT followed by Anomaly Scan (around 18–22 weeks) can catch physical abnormalities
Actionable Tips Before Choosing a Prenatal Test
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Talk to your doctor – Every pregnancy is different
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Know your risk – Age, family history, and previous pregnancies matter
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Check your insurance – NIPT may be partially or fully covered
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Ask about test coverage – Some NIPT tests check more conditions than others
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Choose a certified lab – Accuracy matters, especially with fetal DNA tests
FAQs: NIPT Test vs. Traditional Prenatal Tests
Is NIPT better than traditional tests?
Yes, in terms of accuracy. NIPT has a much higher detection rate for chromosomal conditions like Down syndrome.
Does NIPT replace ultrasound?
No. Ultrasounds check physical development, while NIPT checks chromosomes.
Is NIPT 100% accurate?
Not quite. It’s highly accurate (99%+ for Down syndrome), but not a diagnostic test. Positive results should always be confirmed with CVS or amniocentesis.
Can NIPT detect neural tube defects?
No. You’ll still need a second-trimester scan or blood test for that.
How soon can I do NIPT?
You can take it as early as 10 weeks of pregnancy.
Is NIPT safe?
Absolutely. It’s non-invasive and safe for both mom and baby.
Final Thoughts
Choosing between NIPT and traditional prenatal tests comes down to your needs, preferences, and medical background. If you want early, accurate, and safe screening, NIPT is a great choice.
